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. Author manuscript; available in PMC: 2016 Aug 29.
Published in final edited form as: J Huntingtons Dis. 2016;5(1):65–81. doi: 10.3233/JHD-150181

Fig. 3.

Fig. 3

A. Incubation in T0901317 reduced the average frequency of IPSCs (inset). The amplitude-frequency histogram showed that the reduction occurred across amplitude bins [two-way RM ANOVA, F(5,135)=2.822, p=0.019]. B. The cumulative amplitude histogram showed no change after T0901317 [two-way RM ANOVA, F(6,162)=0.339, p=0.916]. C. The cumulative IEI histogram showed a significant rightward shift after T0901317 indicating a reduced frequency of synaptic events [two-way RM ANOVA, F=(15,405)=3.547, p<0.001]. D. Similar to the effects of the LXR agonist, incubation in Simvastatin reduced the average frequency of IPSCs (inset, Student’s t-test, t=2.312, p=0.027). The amplitude-frequency histogram showed that the reduction occurred across amplitude bins [two-way RM ANOVA, F(5,165), p=0.365 (post hoc tests show p=0.045 for the 10 pA bin and p=0.010 for the 20 pA bin)]. E. Only a sight leftward shift in the cumulative amplitude distribution occurred after T0901317. F. The cumulative IEI histogram showed a significant rightward shift after Simvastatin indicating a reduced frequency of synaptic events [two-way RM ANOVA, F(15,495)=5.001, p<0.001].