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. 2016 Aug 29;7:138. doi: 10.3389/fneur.2016.00138

Table 2.

MRI-CJD consortium criteria for sporadic Creutzfeldt–Jakob disease.

I. Clinical signs

  1. Dementia

  2. Cerebellar or visual

  3. Pyramidal or extrapyramidal

  4. Akientic mutism

II. Tests

  1. Periodic sharp wave complexes in EEG

  2. Protein 14-3-3 detection in CSF (in patients with disease duration of less than 2 years)

  3. High signal abnormalities in caudate nucleus and putamen or at least two cortical regions (temporal–parietal–occipital) either on DWI or FLAIR sequences

Probable CJD: two out of I and at least one out of II.

Possible CJD: two out of I and duration less than 2 years.