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EBV and HCMV expand different NK cell populations. Epstein–Barr virus (EBV) expands early-differentiated NKG2A/CD94, NTB-A, 2B4, CD27, CD16, NKG2D, and DNAM-1-positive NK cells, which after expansion upregulate the senescence marker CD57. Human cytomegalovirus (HCMV) in contrast expands late-differentiated CD94/NKG2C, CD16, CD2, KIR, and CD57-positive NK cells.
