Figure 6.

Comparative expression profiles in chimpanzees and subjects with ASD of candidate genes. Data were obtained from microarray expression datasets available on the Gene Expression Omnibus database (GEO datasets, http://www.ncbi.nlm.nih.gov/gds): GSE28521 (Voineagu et al., 2011) for the temporal and frontal cortices, and GSE38322 (Ginsberg et al., 2012) for the cerebellum of subjects with ASD; GSE22569 (Somel et al., 2011; Liu et al., 2012) for the cerebellum, GSE18142 (Konopka et al., 2009) for the frontal cortex, and GSE7540 (Cáceres et al., 2003) for the temporal cortex of chimps. Data are shown as log transformation of fold changes (logFC) between patients and corresponding controls. Only genes showing statistically significant (p < 0.05) differential expression were considered. Additional details may be found in the Supplemental information file. Note that the plot is intended to display the overall trend of gene expression, given that the relative expression values (i.e., logFC) were obtained from comparative analyses performed on different datasets (based on different designs, samples, and batches).