Table 1.
Creatinine plasma concentration and creatinine clearance (Clcr) in the offspring, submitted to ovariectomy surgery (OVX) or not (Sham), of control (C) and sleep‐restricted (SR) mothers
| Groups | Creatinine (mg/dL) | Clcr (mL/min/kg) | Two‐way ANOVA |
|---|---|---|---|
| 4 months | |||
| Csham (n = 17) | 0.53 ± 0.02 | 4.64 ± 0.21 | Clcr C > SR |
| SRsham (n = 26) | 0.63 ± 0.02* | 3.46 ± 0.17* | P = 0.001 |
| Covx (n = 17) | 0.54 ± 0.02 | 4.39 ± 0.15 | Creatinine C < SR |
| SRovx (n = 26) | 0.65 ± 0.02*, ‡ | 3.21 ± 0.14*, ‡ | P = 0.001 |
| 6 months | |||
| Csham (n = 17) | 0.50 ± 0.02 | 4.81 ± 0.23 | Clcr C > SR |
| SRsham (n = 26) | 0.58 ± 0.02* | 3.81 ± 0.19* | P < 0.001 |
| Covx (n = 17) | 0.50 ± 0.03 | 4.75 ± 0.43 | Creatinine C<SR |
| SRovx (n = 26) | 0.59 ± 0.02*, ‡ | 3.58 ± 0.20*, ‡ | P = 0.001 |
| 8 months | |||
| Csham (n = 17) | 0.53 ± 0.01 | 4.56 ± 0.30 | Clcr C > SR (P = 0.001) |
| SRsham (n = 26) | 0.64 ± 0.02* | 3.37 ± 0.18* | OVX ≠ Sham (P = 0.005) |
| Covx (n = 17) | 0.55 ± 0.02 | 4.09 ± 0.32 | Creatinine C < SR |
| SRovx (n = 26) | 0.68 ± 0.03*, ‡ | 2.48 ± 0.17*, †, ‡ | P = 0.001 |
Significance level: *P < 0.05 versus Csham; † P < 0.05 versus SRsham; ‡ P < 0.05 versus Covx (Bonferroni test). Values are means ± standard error. n, number of animals.