Table 4.
Glomerular area, number of glomeruli, kidney cross‐sectional area, kidney cortical area, and kidney weight in the offspring, submitted to ovariectomy surgery (OVX) or not (Sham), of control (C) and sleep‐restricted (SR) mothers
| Groups | Csham | SRsham | Covx | SRovx | Two‐way ANOVA |
|---|---|---|---|---|---|
| Glomerular area (μm2) | 7936 ± 106 (388) | 7831 ± 108 (404) | 7654 ± 104 (444) | 7365 ± 87*, † (492) |
OVX < Sham (P = 0.0002) SR < C (P = 0.05) |
| Number of glomeruli/mm3 | 91 ± 2 (6) | 96 ± 5 (6) | 106 ± 11 (6) | 119 ± 6* (6) | OVX > Sham (P = 0.008) |
| Kidney cross‐sectional area (mm2) | 104.6 ± 1.7 (6) | 100.4 ± 1.5 (6) | 97.0 ± 2.0* (6) | 90.3 ± 1.8*, ‡ (6) |
SR < C (P = 0.006) OVX < Sham P = 0.0001) |
| Kidney cortical area (%) | 59.2 ± 0.5 (6) | 58.6 ± 0.4 (6) | 58.5 ± 0.3 (6) | 58.2 ± 0.5 (6) | |
| Kidney weight/100 g bw | 0.72 ± 0.02 (17) | 0.65 ± 0.01* (26) | 0.58 ± 0.01* (17) | 0.53 ± 0.01*, †, ‡ (26) |
SR < C (P = 0.0001) OVX < Sham P = 0.0001) |
Significance level: *P < 0.05 versus Csham; † P < 0.05 versus SRsham; ‡ P < 0.05 versus Covx (Bonferroni test).
Values are means ± standard error. n, number of animals. In the glomerular area, the number in parentheses refers to the quantity of glomeruli analyzed.