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Acetylcholine‐induced dilation is attenuated in isolated skeletal muscle arterioles of lean healthy controls (n = 5) (A) and T2DM (n = 6) (B) at 2 h of hyperinsulinemia. Arteriolar dilation was measured in response to increased concentrations of acetylcholine (10‐9 to 10‐4 mole/L) in the absence or presence of L‐NAME. All values are plotted as means ± SE. *(P < 0.05) for L‐NAME and † (P < 0.05) for insulin.
