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. 2016 Aug 22;4(16):e12895. doi: 10.14814/phy2.12895

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© 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Hyperinsulinemia induces ET‐1 protein expression in skeletal muscle of lean healthy controls (LHCs) (n = 8) and T2DM (n = 8). (A) Western blot analysis of ET‐1 protein expression in skeletal muscle homogenate. Signal relative intensity was normalized to GAPDH and results represent the means ± SE for each group. *P < 0.05 for insulin versus basal and † (P < 0.05) for LHCs versus T2DM. (B) Correlation between ET‐1 protein expression and clamp‐derived glucose disposal rate in the study subjects (n = 16).