Table 3. Water solubility and ClogP values for 1,4-diphenethylpiperidine and 1,4-diphenethylpiperazine derivatives.

1,4-Diphenethylpiperidines1 10-20	Solubility (pH = 7.4) mg/mL	ClogP values	1,4-Diphenethylpiperazines 6a-6f and 9a-9e	Solubility (pH =7.4) mg/mL	ClogP values
	0.27	5.69		8.08	3.29
	0.12	5.60		3.16 (33.3)2	3.21
	0.11	5.60		3.16	3.21
	0.16	5.60		3.71	3.21
	0.11	6.28		1.33	3.89
	0.37	5.74		5.94	3.34
	0.30	5.52		1.61 (25.0)2	3.12
	0.26	5.52		1.54	3.12
	0.38	5.52		1.94	3.12
	0.01	6.88		0.08 (13.5)2	4.48
	0.58	5.79		2.39	3.39

¹Structures taken from reference²⁰ (Nickell et al., 2016)

²Experimentally determined water solubility of the hydrochloride salt