Skip to main content
. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Eur Urol. 2015 Jul 10;69(3):428–435. doi: 10.1016/j.eururo.2015.06.046

Table 4.

Histologic definition of new grading system

Grade group 1 (Gleason score 3 + 3 = 6): Only individual discrete well-formed glands
Grade group 2 (Gleason score 3 + 4 = 7): Predominantly well-formed glands with lesser component of poorly formed/fused/cribriform glands
Grade group 3 (Gleason score 4 + 3 = 7): Predominantly poorly formed/fused/cribriform glands with lesser component of well-formed glands†
Grade group 4 (Gleason score 8)
  • -

    Only poorly formed/fused/cribriform glands or

  • -

    Predominantly well-formed glands and lesser component lacking glands††

  • -

    Predominantly lacking glands and lesser component of well-formed glands††

Grade group 5 (Gleason scores 9–10): Lack of gland formation (or with necrosis) with or without poorly formed/fused/cribriform glands †
†

For cases with >95% poorly formed/fused/cribriform glands or lack of glands on a core or at radical prostatectomy, the component of <5% well-formed glands is not factored into the grade.

††

Poorly formed/fused/cribriform glands can be a more minor component.