Table 2.
Outcomes for Completed RCTs (n = 169)
| RCT findings (% of RCTs measuring outcome)** | ||||
|---|---|---|---|---|
| Outcome | N RCTs reporting outcome (% of RCTs)* | Superior | No difference | Inferior |
| Mortality: early (≤ 1 month) | 49 (29%) | 5 (10%) | 44 (90%) | 0 (0) |
| Mortality: late (> 1 month) | 74 (44%) | 17 (23%)^ | 56 (76%)^ | 3 (4%) |
| Mortality: time not stated | 19 (11%) | 2 (11%) | 18 (95%)^ | 0 (0) |
| ICP | 76 (45%) | 30 (39%)^ | 45 (59%)^ | 3 (4%) |
| Length of stay: hospital | 20 (12%) | 0 (0) | 20 (100%) | 0 (0) |
| Length of stay: ICU | 24 (14%) | 7 (29%) | 16 (67%) | 1 (4%) |
| GOS: 6-month | 63 (37%) | 13 (21%) | 51 (81%)^ | 2 (3%)^ |
| GOS: all other time-points | 42 (25%) | 13 (31%) | 29 (69%) | 0 (0) |
| GOSE: 6-month | 11 (7%) | 2 (18%) | 9 (82%)^ | 1 (9%) |
| GOSE: all other time-points | 5 (3%) | 2 (40%) | 3 (60%) | 0 (0) |
| TOTAL (% of all 392 outcomes measured) | 91 (23%) | 291 (74%) | 10 (3%) | |
| TOTAL: CLINICAL OUTCOMES (Mortality, GOS, GOSE: 270 outcomes measured) | 54 (20%) | 210 (78%) | 6 (2%) | |
| TOTAL: SURROGATE ENDPOINTS (ICP, Length of Stay: 122 outcomes measured) | 37 (30%) | 81 (66%) | 4 (3%) | |
*
Will not total 100, as many RCTs measured ≥1 outcome of interest.
**
May not total 100 due to rounding.
^
Multiple measures of outcome with split findings; therefore, total n > total RCTs measuring outcome and total % > 100.
RCT, randomized controlled trial; ICU, intensive care unit; GOS, Glasgow Outcome Score; GOSE, Glasgow Outcome Score-Extended; ICP, intracranial pressure.