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. 2016 Feb 23;21(12):1717–1725. doi: 10.1038/mp.2016.6

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Baseline serotonin concentration GWAS. (a) GWAS for baseline plasma serotonin concentrations revealed a genome-wide significant signal on chromosome 4 as well as a suggestive SNP cluster on chromosome 1. (b) The locus zoom shows that the SNPs on chromosome 1 are across ERICH3. The SNP most highly associated with baseline plasma serotonin concentration from this cluster was rs696692 (P=9.28E-08). (c) The locus zoom for the genome-wide significant SNP cluster on chromosome 4 shows that the SNPs are approximately 15–25 kb 5' of TSPAN5, with rs11947402 as the most highly associated with baseline plasma serotonin concentration (P=7.84E-09). GWAS, genome-wide association study; SNP, single nucleotide polymorphism.