Mean hospital costs in the 5-year period after discharge from index hospitalization in intensive care unit (ICU) survivors compared with hospital control subjects (A) for all patients, (B and C) for patients stratified by age (B, age < 70 yr; C, age ≥ 70 yr), and (D and E) in the presence of Charlson comorbidity (D, no comorbidity; E, one or more comorbidities). Each point represents the mean cost for each quarter (reported as cost per year) for each patient alive at the start of each quarter. Modeling number of admissions rather than costs, age was an effect modifier for the admission rate ratio (ARR) of ICU survivors compared with hospital controls (age < 70 yr: ARR, 1.28; 95% confidence interval [CI], 1.18–1.38; P < 0.001; age ≥ 70 yr: ARR, 1.09; 95% CI, 1.00–1.19; P = 0.05; interaction term, P < 0.001). Similarly, comorbidity is an effect modifier (no comorbidity: ARR, 1.25; 95% CI, 1.17–1.34; P < 0.001; one or more comorbidities: ARR, 1.02; 95% CI, 0.91–1.14; P = 0.72; interaction term, P = 0.02).