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Sequence alignment of three epibatidine-bound pentameric structures, the human α2 nAChR ECD (PDB ID code 5FJV), Ac-AChBP (PDB ID code 2BYQ), and α7-AChBP chimera (PDB ID code 3SQ6). PISA analysis revealed the residues involved in polar interactions (H-bonds, salt bridges; highlighted in green) and in van-der-Waals’ interactions (highlighted in purple). Identical residues are in bold black.
