Fig. S3.

There is a possible link between PHKG2 and cellular iron involving tumor suppressor p53. PHKG2 gene and biomolecules associated with cellular iron were put into a single network space in Ingenuity Pathway Analysis (IPA) software. The “grow” function of IPA software was used to expand the number of edges in the network space, and then the “connect” function was used to identify possible connections among the molecules. This revealed p53 as a hypothetical link between PHKG2 and cellular iron.