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Overall CSPs upon binding the first and second dUMP. The complete effects of binding the first (A) and second (B) dUMP to dimeric TS are shown. Residues with significant CSPs are shown as spheres. Residues that are unassigned or missing are in yellow. In both A and B, the binding subunit CSPs are in purple, and the nonbinding subunit CSPs are in red. The binding dUMP is shown in dark blue. In B, the first bound dUMP is shown in light blue.
