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Global reduction in gDNA 5meCs and 5hmeCs during mouse iPSC differentiation to PGCLCs. (A and B) Density distributions of (A) 5meCs and (B) 5hmeCs. The x axes represent densities of 5meCs or 5hmeCs in 100-bp windows, and the y axes indicate genome-wide frequencies. (C) Heatmaps of 5meC and 5hmeC densities across genomic features. Arrows a-d point to elements retaining 5meCs and/or 5hmeCs in PGCLCs/PGCs.
