Fig. 8.

Ribbon diagram of the core structure of residues 15–42 of Aβ(1–42) within the fibril. The C2 symmetric molecules are shown as yellow and orange spines, respectively. The β-strands are indicated by arrows. The following molecules within the fibril are shown by a surface representation. Positively and negatively charged surface patches are shown in blue and red, respectively, and all hydrophobic residues in white and polar residues in green. Indicated in pink and labeled accordingly are the residues with known familial Alzheimer’s mutations.