Skip to main content
. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Drug Alcohol Depend. 2016 Jun 25;166:51–60. doi: 10.1016/j.drugalcdep.2016.06.020

Figure 2.

Figure 2

Effects of LY379268 and phenmetrazine alone on cocaine self-administration. (A) Effects of the lower (0.03 mg/kg; green) and higher (0.30 mg/kg; blue) doses of LY379268 relative to saline injection on increasing doses of cocaine. (B) LY379268-induced decrease in breakpoints shown in Panel A expressed as a percent of baseline. (C) Phenmetrazine minipumps (25 mg/kg/day; gray bars) significantly reduced breakpoints at each dose of cocaine during self-administration compared to saline minipumps. (D) Phenmetrazine-induced (shaded area) reduction in breakpoint across three cocaine doses in Panel C expressed as a percent of baseline. Number of animals: A, B (0.1875 mg/kg/infusion, n=12; 0.375 mg/kg/infusion, n=8; 0.75 mg/kg/infusion, n=6); C, D (0.1875 mg/kg/infusion, n=6; 0.375 mg/kg/infusion, n=8; 0.75 mg/kg/infusion, n=6). Main effect of treatment on cocaine self-administration: δp<0.05, δδδp<0.001. Post-hoc comparison of LY379268 or phenmetrazine: *p< 0.05, **p<0.01, ***p<0.001 at 0.1875 mg/kg; #p<0.05, ##p<0.01, ###p<0.001 at 0.375 mg/kg cocaine; Δp<0.05, ΔΔp<0.01, ΔΔΔp<0.001 at 0.75 mg/kg cocaine. All doses of cocaine are mg/kg/infusion. Data points are expressed as mean±SEM. Note: In panels A and C, bars are plotted for linear breakpoints on left y-axis and corresponding final response ratios on log scale are plotted on right y-axis for comparison.