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Effect of LY379268 and phenmetrazine alone and in combination on cocaine intake (mg). The highest dose of LY379268 (0.30 mg/kg; blue) alone and phenmetrazine (25 mg/kg/day; gray) alone decreased total cocaine intake significantly at the highest dose of cocaine (0.75 mg/kg). Combining the two drugs (checkered bars) significantly decreased total cocaine intake at all three doses of cocaine *p<0.05; ***p<0.001 relative to saline/vehicle. N=20.
