Table 1.

Summary of individual and combined ability of LY379268 and Phenmetrazine to decrease breakpoints for three doses of cocaine during self-administration.

Cocaine Dose (mg/kg/infusion)	LY379268 (0.03 mg/kg)	LY379268 (0.30 mg/kg)	Phenmetrazine (25 mg/kg/day)	LY379268+Phen (0.03 + 25)	LY379268+Phen (0.30 + 25)
0.1875	18.9**	32.9***	17.7*	63.3***	67.1***
0.375	15.5**	21.7**	18.6**	48.9***	55.1***
0.75	9.69**	24.5**	21.4**	35.7**	49.3**

Note: Data are expressed as a percent decrease in baseline responding and significance pertains to comparisons with baseline responding with no treatment drugs. Phen, phenmetrazine.

^*p<0.05,

^**p<0.01,

^***p<0.001.