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PBC and HMP can provide Hox factors access to targets. (A) Evidence suggests that Hox factors are typically limited to binding DNA in open chromatin regions [119]. (B,C) Expression of PBC and HMP protein has been shown to allow binding of Hox proteins to previously closed chromatin [119]. Prior to Hox binding, HMP and PBC proteins can bind DNA to promote chromatin modifications associated with chromatin opening, such as acetylation [120].
