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. 2016 Aug 29;11(8):e0161486. doi: 10.1371/journal.pone.0161486

Fig 2. Chemical structure and AC50 (μM) of hit compounds in qHTS assays.

Fig 2

For Ca2+ mobilization, values obtained in + EGTA conditions are displayed. Active compounds are considered those with a high quality CRC and efficacy. Efficacy cutoffs are as follow: grp78-luciferase and UPRE-luciferase, >40%; Caspase 3/7 and Ca2+ mobilization, >30%; all cell viability assays, >50%.