Table 2. Plaque classification score in brachiocephalic arteries from ApoE-/- after repeated i.t. instillations of carbon black (CB) and/or lipopolysaccharide (LPS).
Group | Vehicle | Low-dose CB | High-dose CB | LPS | Low-dose CB+LPS | High-dose CB+LPS |
---|---|---|---|---|---|---|
Study 1 | 2.6± 0.6 | 1.8 ± 0.5 | 2.3 ± 0.4 | 2.5 ± 0.5 | 2.7 ± 0.5 | 2.2 ± 0.45 |
Study 2 | 2.2 ± 0.5 | 1.6 ± 0.3 | ND | 1.8 ± 0.3 | ND | ND |
The table presents the classification of atherosclerotic plaque in study 1 and 2 based on morphological characteristics according to the American Heart Association classification guideline [39]. Data in numeric numbers are presented as mean ± SEM calculated from a randomized and blinded scoring of same sections 3 times. The plaque score was not determined (ND) in all groups in study 2.