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Summary of Mean ± SD Exemestane Pharmacokinetic Parameters When Given Alone (Day 7) and in Combination With Fulvestrant (Day 120)
| Parameter | Exemestane Alone (Day 7) | Exemestane + Fulvestrant (Day 120) | % Changea | P Valueb |
|---|---|---|---|---|
| Cmax, ng/mL | 20.1 ± 7.7 | 21.2 ± 11.1 | 5.3 | .9102 |
| AUC 0–24, ng · h/mL | 61.7 ± 17.1 | 54.7 ± 22.9 | −11.3 | .2031 |
| T1/2, h | 7.94 ± 1.32 | 8.44 ± 2.16 | 6.3 | .5469 |
Abbreviation: AUC =area under the curve.
Relative to day 7.
Wilcoxon signed rank test.
