Table 2.

Meta-Analysis of ATP2B1 SNPs With BP Traits

		Millennium GPJ			Global BPgen			CHARGE*			Pooled
SNP	Coded Allele	n (Frequency)	Coefficient (SE), mm Hg	P	n (Frequency)	Coefficient (SE), mm Hg	P	n (Frequency)	Coefficient (SE), mm Hg	P	Coefficient (95% CI), mm Hg	P
SBP
rs1401982	G	13 944 (0.376)	−1.22 (0.23)	1.8×10−7	33 885 (0.385)	−0.30 (0.13)	0.022				−0.52 (−0.74 to −0.30)	3.9×10−6
rs2681472	G	14 032 (0.373)	−1.33 (0.23)	1.2×10−8	33 803 (0.158)	−0.62 (0.18)	5.2×10−4	0.17	−1.29 (0.19)	3.5×10−11	−1.03 (−1.26 to −0.81)	9.9×10−20
rs11105364	G	14 013 (0.364)	−1.34 (0.23)	8.9×10−9	33 877 (0.179)	−0.60 (0.18)	7.4×10−4	0.17	−1.30 (0.19)	4.8×10−11	−1.03 (−1.25 to −0.81)	1.2×10−19
rs11105378	T	13 948 (0.360)	−1.33 (0.23)	1.5×10−8	33 171 (0.158)	−0.59 (0.18)	0.001	0.16	−1.31 (0.20)	9.1×10−11	−1.02 (−1.24 to −0.79)	1.4×10−18
DBP
rs1401982	G	13 944 (0.376)	−0.72 (0.14)	2.0×10−7	33 898 (0.392)	−0.18 (0.09)	0.041				−0.34 (−0.49 to −0.19)	8.1×10−6
rs2681472	G	14 032 (0.373)	−0.65 (0.14)	2.7×10−6	33 829 (0.157)	−0.35 (0.12)	0.003	0.17	−0.64 (0.11)	3.7×10−8	−0.54 (−0.68 to −0.41)	9.7×10−15
rs11105364	G	14 013 (0.364)	−0.70 (0.14)	4.5×10−7	33 898 (0.158)	−0.34 (0.12)	0.004	0.17	−0.63 (0.12)	1.2×10−7	−0.54 (−0.68 to −0.40)	7.5×10−14
rs11105378	T	13 948 (0.360)	−0.70 (0.14)	5.4×10−7	33 183 (0.158)	−0.33 (0.12)	0.005	0.16	−0.62 (0.12)	3.1×10−7	−0.54 (−0.68 to −0.39)	1.6×10−13

Coefficients and SE for SBP and DBP were calculated under the additive model using multiple regression analysis adjusted for age, age², sex, and BMI. In both Millennium GPJ and Global BPgen, adjustment for treatment with antihypertensive medication was achieved by adding fixed constants to measured values (+15 mm Hg for SBP and +10 mm Hg for DBP).² In the Japanese Millennium GPJ and also for some cohorts within Global BPgen, cohort variables were also adjusted to avoid residual population stratification.

^*Results of the CHARGE Study were obtained from the published article.³