Table 2.
The determination of molecular subtypes can be performed using Affymetrix microarrays and the appropriate classification by using the expression of three genes. The clinical difference between the two Luminal B cohorts is still not settled. Probe: Affymetrix HGU133A or HGU133plus2 arrays, N.R.: not relevant ESR1: Estrogen Receptor, HER2: Human Epidermal Growth Factor Receptor 2, MKI67: antigen identified by monoclonal antibody Ki-67.
| Gene | Probe | Cutoff | Basal | Luminal A | Luminal B | HER2 positive | |
|---|---|---|---|---|---|---|---|
| ESR1 | 205225_at | 500 | Low | High | High | High | Low |
| HER2 | 216836_s_at | 4800 | Low | Low | Low | High | High |
| MKI67 | 212021_s_at | 470 | N.R. | Low | High | N.R. | N.R. |