Table 2.
Comparison of genes regulated by CCG-1423 with MKL1-dependent genes from the literature.
| Gene Categories | CCG-1423 | Lat B | DRB | References |
|---|---|---|---|---|
| Total Genes Regulated | 2142 | 608 | 3020 | |
| FBS-MKL1-Dependent Genes (#) (NIH3T3) | 5 out of 28 | 0 out of 28 | 7 out of 28 | [20] |
| FBS-MKL1-Dependent Genes (%) (NIH3T3) | 17.8% | 0.0% | 25.0% | [20] |
| MKL1-Dependent Genes (#) (MDA-MB-231) | 273 out of 1070 | 83 out of 1070 | 271 out of 1070 | [22] |
| MKL1-Dependent Genes (%) (MDA-MB-231) | 25.5% | 7.8% | 25.3% | [22] |
| MKL1-Dependent Genes (#) (B16F2) | 73 out of 323 | 54 out of 323 | 58 out of 323 | [22] |
| MKL1-Dependent Genes (%) (B16F2) | 22.6% | 16.7% | 18.0% | [22] |
Shown are the number and percentage of genes regulated by CCG-1423, Lat B, and DRB that share identity with genes regulated by serum (10% FBS)-induced in an MKL1-dependent manner in NIH3T3 mouse fibroblast cells [20] or those suppressed by knock-down of MTRF-A/B (i.e., MKL1/2-dependent) in aggressive MDA-MB-231 breast cancer cells or B16F2 melanoma cells [22].