Table 2. Inhibition of Human DAAO by Analogues of 11e.

compd	R2	R3	R4	X1	X2	Y	Z	IC50 (μM)a
11e	H	H	H	H	H	O	N	0.07 ± 0.01
11j	Cl	H	H	H	H	O	N	0.10 ± 0.05
11k	H	Cl	H	H	H	O	N	0.06 ± 0.02
11l	H	H	Cl	H	H	O	N	0.04 ± 0.01
11m	F	H	H	H	H	O	N	0.08 ± 0.03
11n	H	F	H	H	H	O	N	0.06 ± 0.02
11o	H	H	F	H	H	O	N	0.05 ± 0.02
11p	CH3	H	H	H	H	O	N	0.08 ± 0.03
11q	H	CH3	H	H	H	O	N	0.07 ± 0.02
11r	H	H	CH3	H	H	O	N	0.09 ± 0.02
11s	H	CF3	H	H	H	O	N	0.10 ± 0.02
11t	H	H	CF3	H	H	O	N	0.08 ± 0.04
11u	OCH3	H	H	H	H	O	N	0.27 ± 0.07
11v	H	OCH3	H	H	H	O	N	0.12 ± 0.03
11w	H	H	OCH3	H	H	O	N	0.12 ± 0.03
15u	OH	H	H	H	H	O	N	0.09 ± 0.04
15v	H	OH	H	H	H	O	N	0.16 ± 0.05
15w	H	H	OH	H	H	O	N	0.11 ± 0.03
11x	H	OPh	H	H	H	O	N	0.24 ± 0.05
11y	H	H	OPh	H	H	O	N	0.08 ± 0.02
11z	H	H	Ph	H	H	O	N	0.05 ± 0.02
19e	H	H	H	CH3	H	O	N	3.3 ± 0.6
19f	H	H	H	F	F	O	N	0.40
22	H	H	H	O	O	O	N	0.85 ± 0.13
23	H	H	H	OH	H	O	N	0.47 ± 0.23
30	H	H	H	H	H	S	N	0.05 ± 0.01
32	H	H	H	H	H	O	CH	0.08 ± 0.01

^aValues are mean ± SD of at least four experiments except for compound 19f (n = 2).