Table 5. Mouse Pharmacokinetics of 8b and 11h (30 mg/kg).

route	parameter	8ba	11h
iv	CL (mL/min/kg)	38.7	10.2
	Vd (L/kg)	0.5	0.8
	T1/2 (h)	0.2	0.9
	AUClast (μg·h/mL)	12.7b	16.3
po	Tmax (h)	0.25	0.08
	Cmax (μg/mL)	6.6	13.8
	AUClast (μg·h/mL)	3.9	12.9
	brain to plasma ratio	NDc	0.01
po/iv	F (%)	31	79

^aIntravenous administration of 8b was conducted at 10 mg/kg.

^bThe value is dose-normalized to 30 mg/kg.

^cNot determined.