Table 2.
Unadjusted and Adjusted HRs (95 CI) per Standard Deviation of Lipid Measurements
| Model 1 | Model 2 | Model 3 | |
|---|---|---|---|
| All Stroke (1031 events) | |||
| LDL-C | 0.95 (0.89–1.02) | 1.01 (0.95–1.08) | 1.06 (0.99–1.13) |
| HDL-C | 0.87 (0.81–0.93)Ɨ | 0.91 (0.84–0.98)Ɨ | 0.97 (0.90–1.04) |
| Triglycerides | 1.07 (1.01–1.13) | 1.09 (1.02–1.16)Ɨ | 1.02 (0.96–1.09) |
| Total Cholesterol | 0.92 (0.87–0.99)Ɨ | 1.00 (0.94–1.07) | 1.06 (0.99–1.13) |
| NonHDL-C* | 0.98 (0.92–1.04) | 1.04 (0.97–1.11) | 1.07 (1.01–1.15) |
| Ischemic Stroke (874 events) | |||
| LDL-C | 0.96 (0.90–1.03) | 1.02 (0.95–1.10) | 1.08 (1.01–1.16)Ɨ |
| HDL-C | 0.86 (0.79–0.92)Ɨ | 0.89 (0.82–0.96)Ɨ | 0.95 (0.87–1.03) |
| Triglycerides | 1.10 (1.03–1.18)Ɨ | 1.12 (1.04–1.20)Ɨ | 1.05 (0.98–1.14) |
| Total Cholesterol | 0.94 (0.87–1.01) | 1.01 (0.94–1.09) | 1.08 (1.00–1.17) |
| NonHDL-C* | 1.00 (0.93–1.07) | 1.06 (0.99–1.14) | 1.10 (1.03–1.18)Ɨ |
| Hemorrhagic Stroke (77 events) | |||
| LDL-C | 0.91 (0.69–1.18) | 1.01 (0.77–1.32) | 1.02 (0.75–1.39) |
| HDL-C | 0.84 (0.65–1.09) | 1.05 (0.80–1.37) | 1.09 (0.83–1.43) |
| Trigylcerides | 0.84 (0.64–1.10) | 0.80 (0.60–1.07) | 0.76 (0.57–1.01) |
| Total Cholesterol | 0.81 (0.62–1.06) | 0.97 (0.73–1.27) | 0.99 (0.72–1.34) |
| NonHDL-C* | 0.86 (0.66–1.13) | 0.95 (0.72–1.24) | 0.95 (0.71–1.28) |
*
Non HDL-C = total cholesterol – HDL
Ɨ
Significant at the .05 level
Model 1: Unadjusted
Model 2: Adjusted for age, race, age*race, gender, education, region, and income
Model 3: Model 2 and addition adjustment for SBP, hypertensive medication use, lipid lowering medication use, smoking, atrial fibrillation, left ventricular hypertrophy, history of heart disease, and diabetes
Abbreviations same as Table 1