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. 2016 Aug 23;11:4107–4124. doi: 10.2147/IJN.S110146

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© 2016 Li et al. This work is published and licensed by Dove Medical Press Limited

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Solubility of drugs and nanoparticles affected by loading and release profile of macrophages.

Notes: (A) Loading concentration of drugs in drug-loaded macrophages at different drug concentrations; (B) EEat different drug concentrations; (C) drug release from drug-loaded macrophages to cell culture medium; (D) macrophages cell viability after incubation with different drugs for 24 hours; (E) SOCnanoparticle diameter assay: (a) before SOCwas swallowed by the macrophages and (b) after SOCwas expelled from the macrophages. Data are expressed as mean ± SD (n=5). *P<0.05.

Abbreviations: DOX, doxorubicin; EE, encapsulation efficiency; NLC, nanostructured lipid carrier; PTX, paclitaxel; SOC, N-succinyl-N′-octyl chitosan; SD, standard deviation.