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. 2016 Aug 23;11:4093–4106. doi: 10.2147/IJN.S105606

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© 2016 Ramos Yacasi et al. This work is published and licensed by Dove Medical Press Limited

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Ex vivo corneal permeation profile of FB from (A) F-A and F-B, (B) NPsTRE and NPsPEG, (C) FD-NPsTRE and FD-NPsPEG, and (D) IR-NPsTRE and IR-NPsPEG, compared with free drug solution after 6 h (mean ± SD, n=3).

Notes: F-A, nanoparticles’ suspension with P188 at 1.66%; F-B, nanoparticles’ suspension with P188 at 3.5%; NPsTRE, formulation prepared with trehalose as a protectant agent; NPsPEG, formulation prepared with PEG3350 as a protectant agent.

Abbreviations: FB, flurbiprofen; FD, freeze-dried condition; IR, irradiated condition; h, hours; SD, standard deviation; NPs, nanoparticles.