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Composition of the freeze-dried optimized NPs formulation
| FB-PεCL-NPs | cFB (mg/mL) | cPεCL (mg/mL) | cP188 (mg/mL) | cPA (mg/mL) |
|---|---|---|---|---|
| FD-NPsTRE | 1.0 | 3.3 | 16.6 | 100 |
| FD-NPsPEG | 1.0 | 3.3 | 35.0 | 160 |
Notes: NPsTRE, formulation prepared with trehalose as a protectant agent; NPsPEG, formulation prepared with PEG3350 as a protectant agent.
Abbreviations: c, concentration; NPs, nanoparticles; FB, flurbiprofen; PεCL, poly(ε-caprolactone); P188, poloxamer 188; PA, protectant agent; FD, freeze-dried condition.
