Table 3.

Parameters for kinetic models of FB-PεCL-NP formulations and free drug solution

Models	Parameters	Units	F-A	NPsTRE	FD-NPsTRE	IR-NPsTRE	F-B	NPsPEG	FD-NPsPEG	IR-NPsPEG	Free drug
Zero order	AIC	–	48.176	47.546	48.385	50.614	47.643	41.204	37.034	43.442	51.021
	r2		0.757	0.762	0.792	0.684	0.762	0.866	0.946	0.819	0.639
First order	AIC	–	22.546	29.845	23.318	27.804	13.193	18.028	11.809	26.027	38.677
	r2		0.997	0.988	0.997	0.993	0.999	0.997	0.999	0.990	0.954
	Kf	minute−1	0.820	0.736	0.510	0.839	0.703	0.455	0.225	0.424	1.054
	SD		0.051	0.097	0.040	0.079	0.022	0.033	0.013	0.062	0.217
	Q∞	µg	91.90	82.81	92.40	94.17	87.22	67.02	81.70	67.25	100.90
	SD		1.484	2.819	1.970	2.287	0.716	1.384	1.954	2.864	5.405
	t1/2	minute	0.845	0.942	1.358	0.827	0.986	1.524	3.079	1.634	0.657
	SD		0.031	0.064	0.127	0.093	0.099	0.008	0.385	0.095	0.039
Hyguchi	AIC	–	42.607	41.874	42.256	46.046	41.950	32.594	24.548	37.685	47.500
	r2		0.904	0.907	0.931	0.853	0.908	0.968	0.993	0.931	0.799
Hyperbola	AIC	–	22.875	27.638	31.732	33.046	26.227	12.467	7.930	30.817	40.655
	r2		0.996	0.991	0.987	0.983	0.993	0.999	0.999	0.978	0.936

Notes: F-A, nanoparticles’ suspension with P188 at 1.66%; NPsTRE, formulation prepared with trehalose as a protectant agent; F-B, nanoparticles’ suspension with P188 at 3.5%; NPsPEG, formulation prepared with PEG3350 as a protectant agent; r², determination coefficient, K_f, release rate constant; Q_∞, maximum amount of dissolved drug; t_1/2, drug half-life.

Abbreviations: FB, flurbiprofen; PεCL, poly(ε-caprolactone); NPs, nanoparticles; FD, freeze-dried condition; IR, irradiated condition; AIC, Akaike’s information criterion; SD, standard deviation.