Skip to main content
. Author manuscript; available in PMC: 2016 Aug 29.
Published in final edited form as: J Am Chem Soc. 2015 Jun 15;137(24):7929–7934. doi: 10.1021/jacs.5b04284

Figure 1.

Figure 1

BRD0476 suppresses inflammatory cytokine-induced human β-cell apoptosis. (a) Chemical structure of BRD0476. (b, c) Caspase-3 activity in dissociated human islets from two independent donor preparations, treated for 6 days with cytokines (a combination of IL-1β, IFN-γ, and TNF-α) and the indicated concentration of BRD0476. (d, e) Glucose-stimulated insulin secretion in dissociated human islets from two independent donor preparations, treated for 6 days with cytokines and the indicated concentration of BRD0476. Data represent the mean ± standard deviation from four individual islet donors; donor information is available in Figure S2. # p < 0.001 compared to no treatment, * p < 0.001, ** p < 0.0001 compared to cytokine treatment, Student’s t test.