. Author manuscript; available in PMC: 2016 Aug 29.

Published in final edited form as: Biochem Soc Trans. 2014 Dec;42(6):1780–1785. doi: 10.1042/BST20140214

Table 1.

GO annotations of PFK1 and murL

Protein Name/Uniprot ID ^a)	GO terms for Primary Function ^b)	Added GO terms for Moonlighting Function ^c)
PFK1/Q92448	GO:0006002-fructose6-phosphate metabolic process GO:0006096-glycolytic process GO:0008152-metabolic process GO:0016310- phosphorylation GO:0046835-carbohydrate phosphorylation GO:0000166-nucleotide binding GO:0003824- catalytic activity GO:0003872-6-phosphofructokinase activity GO:0005524- ATP binding GO:0016301-kinase activity GO:0016740-transferase activity GO:0046872-metal ion binding GO:0005945-6-phosphofructokinase complex GO:0005737- cytoplasm	GO:0016237- microautophagy GO:0010508- positive regulation of autophagy GO:0030242- peroxisome degradation
murL/D3FPC2	GO:0006807-nitrogen compound metabolic process GO:0008152- metabolic process GO:0008360-regulation of cell shape GO:0009252-peptidoglycan biosynthetic process GO:0008881- glutamate racemase activity GO:0016853- isomerase activity GO:0016855-racemase and epimerase activity, acting on amino acids and derivatives GO:0036361-recemerase activity, acting on amino acids and derivatives	GO:0008657- DNA topoisomerase (ATP-hydrolyzing) inhibitor activity GO:2000372- negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity GO:0004857- enzyme inhibitor activity GO:0090143- nucleoid organization

^a)

The name of the moonlighting protein and UniProt ID.

^b)

GO terms in UniProt describing their primary function.

^c)

GO terms we have added for their moonlighting function. No GO terms were found for the moonlighting functions in UniProt.