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. Author manuscript; available in PMC: 2016 Aug 31.
Published in final edited form as: Cell Rep. 2016 Jul 21;16(5):1326–1338. doi: 10.1016/j.celrep.2016.06.076

Figure 3. Virus-Specific Antibody is Required to Control 181/25 Infection.

Figure 3

WT, B cell deficient μMT, or BCR transgenic MD4tr C57BL/6 mice were inoculated in the left rear footpad with 1,000 PFU of AF15561 or 181/25. At 28 dpi, (A) CHIKV RNA in the right ankle was quantified by RT-qPCR, and (B) CHIKV-specific IgG in the serum was quantified by a whole virion-based ELISA. Data are from two or more independent experiments. P values were determined by one-way ANOVA with a Tukey’s multiple comparison test. ****, P < 0.0001.