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. Author manuscript; available in PMC: 2016 Aug 31.
Published in final edited form as: Cell Rep. 2016 Jul 21;16(5):1326–1338. doi: 10.1016/j.celrep.2016.06.076

Figure 4. Virus-Specific Antibody Responses in WT Mice Infected with AF15561 or 181/25.

Figure 4

WT C57BL/6 mice were inoculated in the left rear footpad with 1,000 PFU of AF15561 or 181/25 (n = 5–8 mice per group). At the time points shown, a virion-based ELISA was used to quantify the serum endpoint titers of CHIKV-specific (A) IgM or (B) IgG.

(C) IgG subtype-specific detection antibodies were used to quantify IgG subtypes present in serum at 28 dpi (n = 5–6 mice per group). Data are from two or more independent experiments. P values were determined by two-way ANOVA with a Bonferroni’s multiple comparison test (A, B) and Student’s t-test (C). *, P <0.05, **, P < 0.01; ***, P < 0.001, ****, P < 0.0001.