TABLE 4.
ASSOCIATION OF ADRENAL INSUFFICIENCY WITH OUTCOME USING OTHER DEFINITIONS
| Definition of AI, μg/dl Cortisol | AI | No AI | P Value |
|---|---|---|---|
| Baseline <5, no. | 52 | 330 | |
| Days on catecholamines | 0.15 ± 0.64 | 0.86 ± 1.64 | <0.001 |
| No. of catecholamines | 0.08 ± 0.27 | 0.35 ± 0.58 | 0.001 |
| Fluid boluses, ml/kg/24 h | 0.0 (0.00–6.70) | 0.0 (0.00–9.62) | 0.67 |
| Peak <18, no. | 42 | 341 | |
| Days on catecholamines | 0.64 ± 1.46 | 0.78 ± 1.57 | 0.49 |
| No. of catecholamines | 0.26 ± 0.54 | 0.31 ± 0.56 | 0.49 |
| Fluid boluses, ml/kg/24 h | 5.98 (0.00–21.97) | 5.06 (0.00–20.0) | 0.96 |
| Baseline <5 or peak <18 or increment <9, no. | 163 | 219 | |
| Days on catecholamines | 0.74 ± 1.38 | 0.79 ± 1.68 | 0.57 |
| No. of catecholamines | 0.35 ± 0.59 | 0.28 ± 0.52 | 0.27 |
| Fluid boluses, ml/kg/24 h | 4.81 (0.00–20.0) | 7.69 (0.00–20.37) | 0.82 |
| Baseline and peak <18 and increment <9, no. | 17 | 365 | |
| Days on catecholamines | 0.71 ± 0.99 | 0.77 ± 1.58 | 0.41 |
| No. of catecholamines | 0.47 ± 0.72 | 0.30 ± 0.55 | 0.32 |
| Fluid boluses, ml/kg/24 h | 15.63 (0.00–28.77) | 5.0 (0.00–19.88) | 0.22 |
| Baseline <276 or increment <250, no. | 195 | 186 | |
| Days on catecholamines | 0.73 ± 1.41 | 0.81 ± 1.71 | 0.927 |
| No. of catecholamines | 0.33 ± 0.58 | 0.29 ± 0.53 | 0.611 |
| Fluid boluses, ml/kg/24 h | 4.61 (0.00–20.00) | 8.40 (0.00–20.38) | 0.729 |
Definition of abbreviation: AI = adrenal insufficiency; PICU = pediatric intensive care unit.
Number of days on catecholamines, fluid boluses, days on mechanical ventilation and PICU length of stay are presented as median values (interquartile range). Plus-minus values are means ± SD. Numbers for each definition were derived by using all the patients who had data available for that definition.