Table 1.
Major transcriptional regulators of nonfermentable carbon utilization and their targets
| Transcriptional regulator | Type of DNA-binding domain | Target genes |
|---|---|---|
| Adr1 (alcohol dehydrogenase regulator) | Cys2His2 zinc finger protein | Nonfermentable carbon metabolism (e.g. ADH2, ACS1, GUT1) Peroxisome biogenesis and fatty acids utilization (e.g. POX1, PXA1) |
| Cat8 (CATabolite repression) | Zinc cluster protein | Gluconeogenic genes (e.g. PCK1, FBP1) Glyoxylate cycle genes Transcription factor (SIP4) |
| Ert1 (ethanol regulator of translation) | Zinc cluster protein |
PCK1 Other targets unknown |
| Gsm1 (glucose starvation modulator) | Zinc cluster protein | Gluconeogenesis (PCK1, FBP1) Transcription factor (HAP4) |
| Hap1 (heme activator protein) | Zinc cluster protein | Respiration genes (e.g. CYC1, CYC7) |
| Hap2/3/4/5 (heme activator protein) | CCAAT-binding complex | Respiration genes (e.g. CYC1), TCA cycle |
| Oaf1 (oleate-activated transcription factor) | Zinc cluster protein | Fatty acids utilization (e.g. POX1, FOX3) Peroxisome biogenesis |
| Oaf3 (oleate-activated transcription factor) | Zinc cluster protein | Weak repressor of oleate-responsive genes |
| Pip2 (peroxisome induction pathway) | Zinc cluster protein | Fatty acids utilization (e.g. POX1, FOX3) Peroxisome biogenesis |
| Rds2 (regulator of drug sensitivity) | Zinc cluster protein | Gluconeogenic genes (e.g. PCK1, FBP1) Glyoxylate cycle genes (MLS1, TCA cycle genes) Transcription factors (HAP4, SIP4) |
| Sip4 (Snf1-interacting protein) | Zinc cluster protein | Gluconeogenic genes (e.g. PCK1) |
For references, see text.
TCA, tricarboxylic acid.