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. Author manuscript; available in PMC: 2017 Aug 25.
Published in final edited form as: J Med Chem. 2016 Aug 11;59(16):7617–7633. doi: 10.1021/acs.jmedchem.6b00855

Figure 6.

Figure 6

Two possible docking poses for compound 76. (A) The bromo group is an acceptor of hydrogen bond from C663 and the benzene ring of the indazole stacks with Y111 of the activation loop. (B) A 180° rotation around the benzamide bond leads to both indazole rings stacking with Y111.