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In Vitro Potencies of Newly Synthesized Pyridone Derivatives for EZH2 and EZH1
| |||
|---|---|---|---|
| Cmpd | Structure | IC50(nM) | |
| EZH2 | EZH1 | ||
| 24 |
|
12 ± 2 | >2500 |
| 25 |
|
12 ± 2 | 810 ± 71 |
| 5 |
|
<10 | 69 ± 14 |
| 26 |
|
<10 | 160 ± 14 |
| 27 |
|
<10 | 320 ± 58 |
| 28 |
|
<10 | 86 ± 12 |
| 29 |
|
<10 | 211 ± 46 |
| 30 |
|
73 ± 15 | >5000 |
| 31 |
|
32 ± 9 | >1250 |
| 32 |
|
>10000 | >10000 |
| 33 |
|
>10000 | >10000 |
| 34 |
|
>5000 | >5000 |
| 35 |
|
1016 ± 68 | >5000 |
| 36 |
|
328 ± 74 | >5000 |
| 37 |
|
>2500 | >2500 |
| 38 |
|
32 ± 7 | >2500 |
