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In Vitro Potencies of Newly Synthesized Inhibitors with Modified Indazole Motif
| |||
|---|---|---|---|
| Cmpd | Structure | IC50(nM) | |
| EZH2 | EZH1 | ||
| 5 |
|
<10 | 69 ± 14 |
| 44 |
|
384 ± 70 | >2500 |
| 45 |
|
>5000 | >5000 |
| 46 |
|
>5000 | >5000 |
| 47 |
|
540 ± 91 | >5000 |
| 48 |
|
>5000 | >5000 |
| 49 |
|
>5000 | >5000 |
| 50 |
|
>10000 | >10000 |
