Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In Vitro Potencies of Newly Synthesized Inhibitors with Modifications to the Pyridine-2-yl-piperizine Tail Region
| |||
|---|---|---|---|
| Cmpd | Structure | IC50 (nM) | |
| EZH2 | EZH1 | ||
| 5 |
|
<10 | 69 ± 14 |
| 64 |
|
<10 | 88 ± 22 |
| 65 |
|
<10 | 60 ± 9 |
| 66 |
|
41 ± 10 | >1250 |
| 67 |
|
48 ± 17 | >2500 |
| 68 |
|
66 ± 4 | >1250 |
| 69 |
|
24 ± 4 | 681 ± 90 |
| 70 |
|
22 ± 5 | 773 ± 152 |
| 71 |
|
64 ± 20 | >5000 |
| 72 |
|
11 ± 1 | 613 ± 29 |
| 73 |
|
17 ± 3 | 880 ± 173 |
| 74 |
|
42 ± 7 | >2500 |
| 75 |
|
26 ± 4 | >1250 |
| 76 |
|
35 ± 8 | >5000 |
