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. Author manuscript; available in PMC: 2017 Oct 21.

Published in final edited form as: Eur J Med Chem. 2016 Jun 13;122:102–117. doi: 10.1016/j.ejmech.2016.06.015

Table 5.

The antiproliferative effects of enmein-type diterpenoid derivatives against human cancer cell lines.

Compd	EC₅₀ (μM)
Compd	K562	MGC-803	CaEs-17	Bel-7402
1	4.76	5.69	11.03	7.48
71	8.11	14.21	30.84	32.96
72	2.64	-^a	23.67	15.98
73	1.11	1.99	1.59	1.97
74	0.21	0.93	0.54	1.42
75	0.14	0.61	0.45	1.01
76	0.24	1.22	0.28	0.87
77	0.22	0.80	0.60	0.85
78	0.35	1.27	0.69	1.37
79	0.33	0.46	0.81	0.79
80	0.52	1.54	1.78	1.58
81	0.14	0.34	0.34	0.89
82	0.26	0.82	0.28	0.72
83	1.74	1.16	3.54	0.71

^a

Not available.