Elevated cytoplasmic in high-grade PDCAs. Scoring of Kaiso expression in the cytoplasm and nucleus was compared for grade 1 and grade 2 tumors. (A) Overall, there was elevated expression of cytoplasmic Kaiso (P = 0.0435). (B) For female patients, there was no increase in expression of cytoplasmic or nuclear Kaiso. (C) For males, there was an increase in cytoplasmic Kaiso (P = 0.0013). (D) For stage T2 tumors of females, there was no appreciable difference in cytoplasmic expression. (E) For males, there was an increase in cytoplasmic Kaiso (P = 0.0441) and nuclear Kaiso (P = 0.0236) in tumors >2 cm in size. *P < 0.05 is significant. **P < 0.01 is significant. ***P < 0.001 is significant.