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Proposed model of Kaiso subcellular localization in male and female patients with PDAC. Upregulation of EGFR or constitutively active mutant KRAS is responsible for nuclear localization of Kaiso, ZEB1 and ERK. Nuclear localization of ERK could be responsible for increasing Kaiso expression, and nuclear Kaiso could inhibit the anti-inflammatory effects of nuclear p120ctn and increase the expression of pro-inflammatory cytokines IL-7, IL-3, MCP1, MIP1β, GM-CSF and G-CSF.
