Table 3. Multiple Regression Analysis of NRM at Day 100, Months 6 and 12 with Predicted F-ara-A Clearance (Clpred) in the Independent Cohort.
| Variable | Hazard Ratio (95% CI) at day 100 | p-value | Hazard Ratio (95% CI) at month 6 | p-value | Hazard Ratio (95% CI) at month 12 | p-value |
|---|---|---|---|---|---|---|
| F-ara-A Clpred | ||||||
| <8.50 L/hr | 1.00 | 1.00 | 1.00 | |||
| ≥8.50 L/hr | 0.10 (0.02-0.42) | <0.01 | 0.19 (0.05-0.70) | 0.01 | 0.41 (0.17-1.00) | 0.05 |
| Donor source | ||||||
| Related | 1.00 | 1.00 | 1.00 | |||
| Unrelated (UR) | 4.13 (1.03-16.6) | 0.05 | 2.84 (1.05-7.69) | 0.04 | 3.24 (1.53-6.99) | <0.01 |
| UR cord blood | 3.92 (1.28-12.0) | 0.02 | 2.30 (0.93-5.69) | 0.07 | 1.60 (0.75-3.39) | 0.22 |
| Disease risk | ||||||
| Standard | 1.00 | 1.00 | ||||
| High | 3.98 (0.80-19.7) | 0.09 | 2.94 (0.95-9.12) | 0.06 | NA | NA |
| Comorbidity score | ||||||
| 0 | 1.00 | 1.00 | 1.00 | |||
| 1-2 | 3.12 (0.93-10.5) | 0.07 | 2.77 (1.19-6.48) | 0.02 | 2.08 (1.02-4.25) | 0.04 |
| ≥3 | 2.20 (0.70-6.96) | 0.18 | 1.48 (0.58-3.80) | 0.41 | 1.66 (0.82-3.36) | 0.16 |
| Acute GVHD (grades II-IV) before NRM | ||||||
| No | 1.00 | 1.00 | 1.00 | |||
| Yes | 2.40 (0.92-6.30) | 0.07 | 2.62 (1.22-5.60) | 0.01 | 3.23 (1.69-6.18) | <0.01 |
NA is not applicable and indicates that the covariate was not significant in the multivariate full model (p >0.20) and was eliminated in the final reduced model.