Table 4. Multiple Regression Analysis of NRM at Day 100, Months 6 and 12 with Predicted F-ara-A AUCpred in the Independent Cohort.
| Parameter | Hazard Ratio (95% CI) at 100 days | p-value | Hazard Ratio (95% CI) at 6 months | P value | Hazard Ratio (95% CI) at 12 months | p-value |
|---|---|---|---|---|---|---|
| F-ara-A AUCpred | ||||||
| <6.00 (μg*hr/mL) | 1.00 | 1.00 | 1.00 | |||
| ≥6.00 (μg*hr/mL) | 5.30 (1.59-17.7) | 0.01 | 2.42 (0.87-6.77) | 0.09 | 2.67 (1.31-5.43) | 0.01 |
| Donor source | ||||||
| Related | 1.00 | 1.00 | 1.00 | |||
| Unrelated (UR) | 4.32 (1.16-16.06) | 0.03 | 2.79 (1.06-7.31) | 0.04 | 3.35 (1.59-7.05) | <0.01 |
| UR cord blood | 1.91 (0.55-6.67) | 0.31 | 1.71 (0.70-4.13) | 0.24 | 1.33 (0.61-2.86) | 0.47 |
| Disease risk | ||||||
| Standard | 1.00 | 1.00 | ||||
| High | 2.84 (0.87-9.33) | 0.08 | 2.27 (0.91-5.65) | 0.08 | NA | NA |
| Comorbidity score | ||||||
| 0 | 1 | 1 | 1 | |||
| 1-2 | 2.27 (0.72-7.13) | 0.16 | 2.42 (1.04-5.62) | 0.04 | 1.93 (0.93-4.01) | 0.08 |
| ≥3 | 2.83 (0.83-9.57) | 0.10 | 1.72 (0.66-4.48) | 0.27 | 1.80 (0.88-3.68) | 0.11 |
| Acute GVHD (grades II-IV) before NRM | ||||||
| No | 1.00 | 1.00 | 1.00 | |||
| Yes | 1.89 (0.71-5.00) | 0.20 | 2.35 (1.07-5.15) | 0.03 | 3.04 (1.62-5.73) | <0.01 |
NA is not applicable and indicates that the covariate was not significant in the multivariate full model (p >0.20) and was eliminated in the final reduced model.